How Forskolin Works for Weight Loss

How Forskolin WorksForskolin acts primarily by activating the enzyme adenylate cyclase, which results in increased cyclic adenosine monophosphate (cAMP) in cells. Thus, Forskolin can increase cyclic AMP without the assistance of neurotransmitters or hormones.

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How Forskolin Works

Forskolin is an effective smooth-muscle relaxer, resulting in bronchodilation, decreased airway resistance, and increased vital capacity and forced expiratory volume, which are important indicators of pulmonary function. Forskolin also has tremendous antispasmodic action on various smooth muscles in the body, making it useful to relieve intestinal colic, uterine cramps, painful urination, angina, and hypertension.

Cardiovascular Effects of Forskolin

Treating these conditions may be among the most useful uses for Forskolin. Forskolin's basic cardiovascular action is to lower blood pressure, while simultaneously increasing the contractility of the heart. Forskolin administration dramatically improved left ventricular function and overall cardiovascular performance.

Increased cellular cyclic AMP results in a broad range of biochemical and physiological effects, including inhibition of platelet activation (resulting in decreased likelihood of blood clots), reduced release of histamine (resulting in decreased allergy symptoms), increased force of contraction of the heart, relaxation of the arteries and other smooth muscles, increased thyroid function, and increased lipolysis (fat burning).

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A number of diseases are characterized, in part, by decreased intracellular levels of cyclic AMP. These include asthma, eczema, psoriasis, angina, hypertension and obesity. In addition to its adenylyl cyclase-stimulating actions, Forskolin also appears to have actions that are not due to this mechanism, but are due to its ability to alter a number of membrane transport proteins.

Asthma and Allergies

Forskolin also increases cerebral blood flow, indicating that it may be beneficial in cerebral vascular insufficiency and in enhancing post-stroke recovery. The platelet aggregation-inhibiting effects of Forskolin also add to its value in cardiovascular disorders.

This mechanism is the “flip side” of Forskolin's ability to act directly to increase cAMP. Thus, Forskolin can be used by itself, or in addition to phosphodiesterase-inhibiting drugs in the prevention and treatment of many allergic conditions, including asthma.

Glaucoma and Increased Intraocular Pressure

Depression is believed to be due to an imbalance of neurotransmitters in the brainâ most commonly either serotonergic (inhibitory) or dopaminergic (stimulatory). If the dopaminergic (i.e., catecholamines like epinephrine or noradrenaline) neurotransmitters are deficient, catecholamine precursors such as the amino acids L-Phenylalanine or L-Tyrosine, or monoamine oxidase inhibitors such as GeroVital (GH3) or Deprenyl are most likely to help.

A number of studies have shown that topical application of one percent Forskolin eye drops resulted in significant decreases in intraocular pressure for up to five hours. Researchers believe that it is the cAMP-elevating effects of Forskolin that result in this significant improvement. Clinical experience is limited, oral Forskolin appears to offer significant potential for sufferers of glaucoma or intraocular hypertension, and may be a major advance in the non-drug treatment of this condition.

Psoriasis

This imbalance results in a tremendous increase in cell division. Forskolin helps to alleviate psoriasis by normalizing the cAMP/ cGMP ratio. Forskolin and Evening Primrose Oil may both be considered as additional substances to be added to a regimen to treat this particularly vexatious disease.

Depression

Based on the human studies for weight loss, 50 to 100 mg of Forskolin taken in divided doses during the day appears to be a safe, effective dose for the conditions discussed above.

German scientists have been working with a different approach to elevating catecholamines, using a class of drugs that stimulate both the presynaptic as well as the postsynaptic components of catecholamanergic transmission. This novel approach uses a drug, Rolipram, which acts by increasing cAMP (an action similar to that of Forskolin), and inhibiting phosphodiesterase. The researchers stopped short of recommending Forskolin for the treatment of depression, they stated clearly that “elevated brain cAMP levels are closely linked to antidepressant activity in animal models of depression.”.

Weight Loss.

Forskolin also has demonstrated the ability to increase thyroid hormone production and stimulate thyroid hormone release. This mechanism of stimulating the thyroid to enhance metabolism may be one way in which Forskolin promotes normal body weight. Forskolin's effects in normalizing thyroid function may also contribute to its antidepressant effects, as depression is a common feature of hypothyroidism.

How Forskolin WorksCancer Metastases.

Forskolin also exhibits potent immune system enhancement by activating lymphocytes and macrophages.

How Forskolin Works: Dosage

Scientists at Brown University confirmed that Forskolin is a potent inhibitor of platelet aggregation, as well as being a potent inhibitor of tumor colonization in mice. They suggested that Forskolin could find a place in the prevention of tumor metastases.

How Forskolin Works: Immune Enhancement

Forskolin acts primarily by activating the enzyme adenylate cyclase, which results in increased cyclic adenosine monophosphate (cAMP) in cells. Thus, Forskolin can increase cyclic AMP without the assistance of neurotransmitters or hormones.

Forskolin's basic cardiovascular action is to lower blood pressure, while simultaneously increasing the contractility of the heart. Six overweight women took 25 mg of Forskolin (250 mg capsules of 10 percent standardized Forskolin extract) twice daily for eight weeks. Forskolin also has demonstrated the ability to increase thyroid hormone production and stimulate thyroid hormone release.

Based on these findings and in vitro studies, scientists theorized that Forskolin might be an effective weight loss agent, especially for those with impaired cAMP production. Six overweight women took 25 mg of Forskolin (250 mg capsules of 10 percent standardized Forskolin extract) twice daily for eight weeks. These preliminary results indicate that Forskolin may be a safe, useful adjunct to losing weight and maintaining normal body composition.

How Forskolin Works

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